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CCDC103 is a Histone Deacetylase required for germline stem cell survival.
The maintenance of GSCs during oogenesis and spermatogenesis requires a tightly regulated transcriptional program. We show that the histone deacetylase CCDC103 plays a key role in regulating germline transcription during oogenesis. Its loss results in GSC loss in the ovary and in the postmeiotic spermatids of male germ cells. CCDC103 is enriched in the foci of H3K4me3-modified histones, and CCDC103 depletion decreases H3 0b46394aab